The hospital carried out 375 more operations during October than it did in the same month last year, bringing the total to 3,959, the hospital authorities said in a statement.
On average, 128 operations were carried out every day. Out of the total number of operations, 3,374 were planned while 585 were emergency procedures.
The increase in the number of operations was the result of a programme which makes better use of operating theatres and has expanded to an extra two theatres in the orthopaedic department, Health Minister Joe Cassar said.
Between January and October, 36,489 operations were carried out.