The St Thomas Moore chapel within the University of Malta was conceived soon after operations began on the new campus. It was designed in the mid-1970s by architect Lino Gatt and executed by William Micallef. By the end of 1978, the chapel was in full use.

The site where the chapel now stands was originally surrounded by fields contained by terraced rubble walls.

The sloping agricultural nature of the area inspired the architect to design the chapel to take into consideration the surrounding environment, opting to design a more organic piece of modern architecture. The extent of curvature in the walls and roof structure represents the willingness of the architect to design a building that embraces its surroundings rather than dominating it.

This is also evident in the downward approach through the entrance of the chapel into a semi-circular auditorium-styled interior where the service takes place. The raised roof over the altar emits an abundance of natural light aided by the high level horizontal strip windows within the external walls of the chapel.

The Malta Environment and Planning Authority scheduled St Thomas Moore chapel as a Grade 2 building.