Russia's Daniil Medvedev advanced to his first Grand Slam semi-final Tuesday at the US Open by defeating three-time major winner Stan Wawrinka while Roger Federer eyed his 46th Grand Slam semi-final berth.

Fifth seed Medvedev's 7-6 (8/6), 6-3, 3-6, 6-1 triumph sent him into a Friday matchup against the later winner between Bulgaria's 78th-ranked Grigor Dimitrov and 38-year-old Federer, owner of a record 20 Grand Slam titles.

"I'm really happy to be in my first semi-final," Medvedev said.

Medvedev struggled with a sore left quadriceps muscle that had him think about quitting the match in the first set. 

"Before the match I was feeling perfect. In the first set I think I pulled my quadriceps," Medvedev said.

"I had a really big pain in my quadriceps and thought I wasn't going to continue the match."

Medvedev took a medical timeout and had the area taped and took a painkiller.

"In the fourth set, I started feeling the painkiller and started moving better," he said. "For sure I hope to be ready for the semis."

Medvedev, at 23, becomes the youngest US Open semi-finalist since Novak Djokovic in 2010 and Russia's first Slam semi-finalist since Mikhail Youzhny at the 2010 US Open.

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