Nine Premier League players have been suspended for one game.
Valletta defenders Jason Lee Vandelannoite, sent off in the 4-2 defeat against Hibs, and Jonathan Caruana, who collected his fourth yellow card during last weekend's game, will miss their team's match against Mosta on Saturday.
Title candidates Hibs will also be without key players for Sunday's derby against Tarxien after goalkeeper Mario Muscat and striker Jean Paul Farrugia were given a one-match ban.
Muscat saw red in the closing stages of Hibs' win over Valletta while Farrugia received his fourth yellow card.
Relegation strugglers Ħamrun Spartans, who meet Balzan on Monday, had Bledjon Guga and David Camilleri on the suspensions' list, both for four yellow cards.
Qormi's Luke Sciberras, sent off in the 4-2 loss to Floriana, will miss his side's clash with Rabat Ajax for whom Dylan Falzon also incurred a one-match ban for four yellow cards.
Melita have lost Manuel Ramon Sierra Camacho, suspended for four cautions, for their match against Floriana on Monday.