Ryanair has just released six million seats for use in October and November for just €10 one way, including taxes and charges.
From Malta the offer is valid for flights to and from Pisa, Bari and Valencia.
Tickets can be booked only on www.ryanair.com up to Sunday, the airline said.
Company spokesman Alessia Viviani said the sale proved that Ryanair would continue to replace the era of low-fare air travel with a new period of lowest ever airfares.
"Ryanair guarantees that no one will beat our fares so we urge passengers to book these €10 seats for October and November on www.ryanair.com before midnight on Sunday."
Only Ryanair, she said, guaranteed the lowest fares and no fuel surcharge.