Triq il-Kottonera, from corner with Triq San Dwardu to corner with Triq il-Ġublew tal-Fidda, will be closed to vehicular traffic on Friday from 9 a.m.
Transport Malta said this was due to scarifying and resurfacing works.
Vehicular traffic from Triq San Nikola will be diverted to Triq il-Ġublew tal-Fidda, Triq San Dwardu and Triq il-Kottonera.
Vehicular traffic from Triq il-Kottonera will be diverted to Triq San Dwardu and Triq Santa Tereża and ix-Xatt ta' Bormla.
Vehicular traffic from Triq Santa Tereża will be diverted to Triq San Dwardu and Triq Il-Kottonera.
Residents will be permitted access their residences, TM said.