A 33-year old man was arrested in Fgura on Wednesday after 1.5 kilos of cocaine were found in his car ready for trafficking.
Police said further searches of the man's garage in a complex in Ħamrun yielded around 11.5 kilos of cannabis.
A 27-year old man from Mosta was also arrested in relation to the ongoing investigation, police said.
The pair are expected to be arraigned on Wednesday. Magistrate Aaron Bugeja is leading an inquiry.