Three people had to be evacuated on Friday afternoon from an apartment block in Msida, one of them from the balcony via a fire ladder.
A witness said the other two managed to get down the apartment's stairwell, escorted by firemen.
The fire broke out Triq il-Qroqq at 1.55pm but has now been put out, according to the witness.
The surrounding roads, which had been closed off to traffic at one point, have been opened.
One person had to be rescued from his balcony by fire ladder.