An ingredient in the yellow curry spice turmeric may hold the key to repairing the brains of people with neurodegenerative diseases such as Alzheimer’s, research suggests.
In laboratory tests, aromatic turmerone promoted the proliferation of brain stem cells and their development into neurons.
The bio-active compound could help scientists develop treatments for conditions in which brain cells are lost, including Alzheimer’s and stroke, it is claimed.
Adele Rueger, from the Institute of Neuroscience and Medicine in Julich, Germany, said: “While several substances have been described to promote stem cell proliferation in the brain, fewer drugs additionally promote the differentiation of stem cells into neurons, which constitutes a major goal in regenerative medicine.
“Our findings on aromatic turmerone take us one step closer to achieving this goal.”
The scientists examined the effect of aromatic turmerone on endogenous neutral stem cells (NSCs) found within adult brains.
Our findings on aromatic turmerone take us one step closer to achieving this goal
NSCs go on to develop into neurons, and play an important role in recovery from neuro-degenerative diseases.
At certain concentrations, the turmeric compound boosted the proliferation of rat foetal NSCs by up to 80 per cent, and increased the speed at which they matured.
In living rats, injections of aromatic turmerone led to the expansion of two key brain regions, the sub ventricular zone (SVZ) and hippocampus.
Both are sites in adult mammalian brains where neurogenisis − the growth of new neurons − is known to occur.
The findings are published in the online journal Stem Cell Research & Therapy.
Laura Phipps, from Alzheimer’s Research UK, said: “This early-stage study highlights the effects of aromatic turmerone in rat brains, but the findings are a long way from determining whether this compound could help fight diseases like Alzheimer’s.
“It’s not clear whether the results of this research would translate to people, or whether the ability to generate new brain cells in this way would benefit people with Alzheimer’s disease.
“We’d need to see further studies to fully understand this compound’s effects in the context of a complex disease like Alzheimer’s, and until then people shouldn’t take this as a sign to stock up on supplies of turmeric for the spice rack.
“The death of brain cells is a key feature of Alzheimer’s, and investment in research is crucial to understand how this cell death occurs and how to intervene.
“It takes many years for fundamental research such as this to be translated into new treatments, and for the best chance of success we need to see a range of approaches being taken.”
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