An Isuzu ended up in a field near Triq ir-Rabat in Nadur after a collision with a Kia at 6.45am on Wednesday.
The police said that the Isuzu was being driven by a 43-year-old from from St Julians while the Kia was being driven by a 68-year-old from Żebbuġ, Gozo.
Both the drivers were seriously injured.
Investigations are still under way.
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