Israeli archaeologists on Monday uncovered a Byzantine-era, industrial-scale wine complex which produced some two million litres of the drink annually and was the world's "largest" such centre at the time.

The facility in Yavne, south of Tel Aviv that was a Jewish settlement during biblical times and a key city after the destruction of Jerusalem in 70 AD, is comprised of five wine presses sprawling over a square kilometre.

The 1,500-year-old site covers warehouses for ageing and marketing the wine, kilns for preparing the clay amphorae used to store the wine and "tens of thousands of fragments and intact earthen jars", the Israel Antiquities Authority said of the "sophisticated" site.

Israel Antiquities Authority archaeologist Liat Nadav-Ziv presents the Byzantine-period Gazan jars.

The produce was known as "Gaza and Ashkelon wine" due to the nearby ports from which it was exported, according to IAA excavators Elie Hadad, Liat Nadav-Ziv and Jon Seligman, who said the Holy Land wine was a prized product.

Fermenting grape juice into wine was a proven way in antiquity to avoid illness from contaminated drinking water.

The dig, which lasted two years, revealed Persian-era wine presses aged 2,300 years old at the same site.

Archaeologists and technicians of the Israel Antiquities Authority excavate inside a winepress at the Tel Yavne site.