Three Britons - Mark Andrew Buckley, 25, Jamie Thomas Carter, 30, and Daniel Emile Degisi, 24, have been remanded in custody after they pleaded not guilty to conspiring to traffic, importing and trafficking cocaine.
They were also charged with having the drug in their possession in circumstances which denoted it was not for their personal use.
The three men were arrested after the police found 220 grammes of cocaine in their hotel room in Bugibba.
One tried to leave Malta on a ferry to Sicily after realising that the drug had been found by the police.